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1

Safe Innovation Approach: Towards an agile system for dealing with innovations

Soeteman-Hernandez, Lya G., Apostolova, Margarita D., Bekker, Cindy, Dekkers, Susan, Grafström, Roland C., Groenewold, Monique, Handzhiyski, Yordan, Herbeck-Engel, Petra, Hoehener, Karl, Karagkiozaki,

Journal:

Materials Today Communications

Year:

2019

Language:

english

File:

PDF, 1.87 MB

english, 2019

2

RDFIO: extending Semantic MediaWiki for interoperable biomedical data management

Lampa, Samuel, Willighagen, Egon, Kohonen, Pekka, King, Ali, Vrandečić, Denny, Grafström, Roland, Spjuth, Ola

Journal:

Journal of Biomedical Semantics

Year:

2017

Language:

english

File:

PDF, 2.00 MB

english, 2017

3

Intrinsic differences in cisplatin sensitivity of head and neck cancer cell lines: Correlation to lysosomal pH

Cathrine Nilsson, Karin Roberg, Roland C. Grafström, Karin Öllinger

Journal:

Year:

2010

Language:

english

File:

PDF, 390 KB

english, 2010

4

Transcript profiling of enzymes involved in detoxification of xenobiotics and reactive oxygen in human normal and simian virus 40 T antigen-immortalized oral keratinocytes

Martin Vondracek, David A. Weaver, Zsolt Sarang, Jesper J. Hedberg, James C. Willey, Lars Wärngård, Roland C. Grafström

Journal:

International Journal of Cancer

Year:

2002

Language:

english

File:

PDF, 144 KB

english, 2002

5

Effects of areca nut on growth, differentiation and formation of DNA damage in cultured human buccal epithelial cells

Kristina Sundqvist, Roland C. Grafström

Journal:

International Journal of Cancer

Year:

1992

Language:

english

File:

PDF, 1.83 MB

english, 1992

6

Differences in Metabolism of Chemical Carcinogens in Cultured Human Epithelial Tissues and Cells

Curtis C. Harris, Benjamin F. Trump, Roland Grafstrom, Herman Autrup

Journal:

Journal of Cellular Biochemistry

Year:

1982

Language:

english

File:

PDF, 561 KB

english, 1982

7

Growth-associated modifications of low-molecular-weight thiols and protein sulfhydryls in human bronchial fibroblasts

Luigi Atzori, Jeannette M. Dypbukt, Kristina Sundqvist, Ian Cotgreave, Charlotte C. Edman, Peter Moldéus, Roland C. Grafström

Journal:

Journal of Cellular Physiology

Year:

1990

Language:

english

File:

PDF, 780 KB

english, 1990

8

Analysis of proliferation, apoptosis and keratin expression in cultured normal and immortalized human buccal keratinocytes

Annette Hansson, Balvinder K. Bloor, Zsolt Sarang, Ylva Haig, Peter R. Morgan, Hans-Jürgen Stark, Norbert E. Fusenig, Jan Ekstrand, Roland C. Grafström

Journal:

European Journal of Oral Sciences

Year:

2003

Language:

english

File:

PDF, 287 KB

english, 2003

9

Computational toxicology using the OpenTox application programming interface and Bioclipse

Egon L Willighagen, Nina Jeliazkova, Barry Hardy, Roland C Grafström, Ola Spjuth

Journal:

BMC Research Notes

Year:

2011

Language:

english

File:

PDF, 917 KB

english, 2011

10

Multiple genotypic aberrances associate to terminal differentiation-deficiency of an oral squamous cell carcinoma in serum-free culture

Karin Roberg, Rebecca Ceder, Lovisa Farnebo, Lena Norberg-Spaak, Roland C. Grafström

Journal:

Differentiation

Year:

2008

Language:

english

File:

PDF, 1.24 MB

english, 2008

11

Combining factors on protein and gene level to predict radioresponse in head and neck cancer cell lines

Lovisa Farnebo, Fredrik Jerhammar, Rebecca Ceder, Roland C. Grafström, Linda Vainikka, Lena Thunell, Reidar Grénman, Ann-Charlotte Johansson, Karin Roberg

Journal:

Journal of Oral Pathology & Medicine

Year:

2011

Language:

english

File:

PDF, 250 KB

english, 2011

12

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

Selivanova, Galina, Iotsova, Violetta, Okan, Ismail, Fritsche, Michael, Ström, Marika, Groner, Bernd, Grafström, Roland C., Wiman, Klas G.

Journal:

Nature Medicine

Year:

1997

File:

PDF, 894 KB

1997

13

Cytotoxicity, thiol depletion and inhibition of O6-methylguanine-DNA methyltransferase by various aldehydes in cultured human bronchial fibroblasts

Krokan, Hans, Grafstrom, Roland C., Sundqvist, Kristina, Esterbauer, Hermann, Harris, Curtis C.

Journal:

Year:

1985

Language:

english

File:

PDF, 519 KB

english, 1985

14

Growth regulation of serum-free cultures of epithelial cells from normal human buccal mucosa

Kristina Sundqvist, Yun Liu, Kristina Arvidson, Kari Ormstad, Lennart Nilsson, Rune Toftgård, Roland C. Grafström

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1991

Language:

english

File:

PDF, 909 KB

english, 1991

15

The mechanism of Hg2+ toxicity in cultured human oral fibroblasts: The involvement of cellular thiols

Yun Liu, Ian Cotgreave, Luigi Atzori, Roland C. Grafström

Journal:

Chemico-Biological Interactions

Year:

1992

Language:

english

File:

PDF, 659 KB

english, 1992

16

Mutagenicity of formaldehyde in chinese hamster lung fibroblasts: Synergy with ionizing radiation and N-nitroso-N-methylurea

Roland C. Grafström, Ih'-Chang Hsu, Curtis C. Harris

Journal:

Chemico-Biological Interactions

Year:

1993

Language:

english

File:

PDF, 558 KB

english, 1993

17

In vitro studies of aldehyde effects related to human respiratory carcinogenesis

Roland C. Grafström

Journal:

Mutation Research/Reviews in Genetic Toxicology

Year:

1990

Language:

english

File:

PDF, 858 KB

english, 1990

18

Mutagenesis of xeroderma pigmentosum fibroblasts by acrolein

Rodger D. Curren, Li L. Yang, Patricia M. Conklin, Roland C. Grafstrom, Curtis C. Harris

Journal:

Mutation Research Letters

Year:

1988

Language:

english

File:

PDF, 437 KB

english, 1988

19

The Janus face of alcohol dehydrogenase 3

Claudia A. Staab, Johan Ålander, Ralf Morgenstern, Roland C. Grafström, Jan-Olov Höög

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 649 KB

english, 2009

20

Medium-chain fatty acids and glutathione derivatives as inhibitors of S-nitrosoglutathione reduction mediated by alcohol dehydrogenase 3

Claudia A. Staab, Mikko Hellgren, Roland C. Grafström, Jan-Olov Höög

Journal:

Chemico-Biological Interactions

Year:

2009

Language:

english

File:

PDF, 433 KB

english, 2009

21

Matrix metalloproteinase-7 and -13 expression associate to cisplatin resistance in head and neck cancer cell lines

Anna Ansell, Fredrik Jerhammar, Rebecca Ceder, Roland Grafström, Reidar Grénman, Karin Roberg

Journal:

Year:

2009

Language:

english

File:

PDF, 255 KB

english, 2009

22

Mechanistic and dose considerations for supporting adverse pulmonary physiology in response to formaldehyde

Chad M. Thompson, Ravi P. Subramaniam, Roland C. Grafström

Journal:

Toxicology and Applied Pharmacology

Year:

2008

Language:

english

File:

PDF, 396 KB

english, 2008

23

Formation of DNA adducts in human buccal epithelial cells exposed to acetaldehyde and methylglyoxal in vitro

Carlos E Vaca, Jan Anders Nilsson, Jia-Long Fang, Roland C Grafström

Journal:

Chemico-Biological Interactions

Year:

1998

Language:

english

File:

PDF, 151 KB

english, 1998

24

In vitro culture of human thymic epithelial cells in serum-free media

BIRGER CHRISTENSSON, PETER BIBERFELD, ROLAND GRAFSTRÖM, GEORG MATELL

Journal:

Year:

1989

Language:

english

File:

PDF, 2.10 MB

english, 1989

25

Metabolism of Extracellular Glutathione in Rat Small-Intestinal Mucosa

Roland GRAFSTRÖM, A. Howard STEAD, Sten ORRENIUS

Journal:

Year:

1980

Language:

english

File:

PDF, 656 KB

english, 1980

26

Benzo(α)pyrene metabolism by isolated rat intestinal epithelial cells

Sidney J. Stohs, Roland C. Grafström, M.Danny Burke, Sten Orrenius

Journal:

Archives of Biochemistry and Biophysics

Year:

1977

Language:

english

File:

PDF, 927 KB

english, 1977

27

Paracetamol metabolism in the isolated perfused rat liver with further metabolism of a biliary paracetamol conjugate by the small intestine

Roland Grafström, Kari Ormstad, Peter Moldéus, Stem Orrenius

Journal:

Biochemical Pharmacology

Year:

1979

Language:

english

File:

PDF, 850 KB

english, 1979

28

Differential effects of disulfiram and diethyldithiocarbamate on small intestinal and liver microsomal benzo[a]pyrene metabolism

Roland Grafström, Frank E. Greene

Journal:

Biochemical Pharmacology

Year:

1980

Language:

english

File:

PDF, 772 KB

english, 1980

29

Differentiation-Promoting Culture of Competent and Noncompetent Keratinocytes Identifies Biomarkers for Head and Neck Cancer

Rebecca Ceder, Ylva Haig, Marina Merne, Annette Hansson, Xi Zheng, Karin Roberg, Matthias Nees, Kristiina Iljin, Balvinder K. Bloor, Peter R. Morgan, Bengt Fadeel, Roland C. Grafström

Journal:

The American Journal of Pathology

Year:

2012

Language:

english

File:

PDF, 1.66 MB

english, 2012

30

A novel infrastructure for chemical safety predictions with focus on human health

Ola Spjuth, Egon Willighagen, Ulf Hammerling, Lennart Dencker, Roland Grafström

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 83 KB

english, 2012

31

Computational toxicology using OpenTox & Bioclipse

Egon Willighagen, Ola Sjuth, Roland Grafström

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 83 KB

english, 2012

32

Developing a novel QSAR framework for nanomaterial toxicity

Egon Willighagen, Hanna Karlsson, Roland Grafström, Bengt Fadeel

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 98 KB

english, 2012

33

Sharing dose response data and analysis across the SEURAT-1 cluster

Egon Willighagen, Christoph Helma, Emilio Benfenati, Nina Jeliazkova, Jeff Wiseman, Roland Grafström, Barry Hardy, Glenn Myatt, Glyn Stacey

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 87 KB

english, 2012

34

Bioinformatics-based cancer research have wide toxicological applicability

Roland C. Grafström, Rebecca Ceder, Bengt Fadeel, Karin Roberg, Egon Willighagen

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 86 KB

english, 2012

35

Toxicogenomic profiling of formaldehyde-dependent effects in vitro

Rebecca Ceder, Marina Merne, Jan-Anders Nilsson, Claudia Staab, Jan-Olov Höög, Roland C. Grafström

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 88 KB

english, 2012

36

Probabilistic toxicogenomics studies in vitro

Juuso Parkkinen, Rebecca Ceder, Egon Willighagen, Krister Wennerberg, Samuel Kaski, Roland Grafström

Journal:

Toxicology Letters

Year:

2012

Language:

english

File:

PDF, 88 KB

english, 2012

37

Expression of Alcohol Dehydrogenase 3 in Tissue and Cultured Cells from Human Oral Mucosa

Jesper J. Hedberg, Jan-Olov Höög, Jan A. Nilsson, Zheng Xi, Åsa Elfwing, Roland C. Grafström

Journal:

The American Journal of Pathology

Year:

2000

Language:

english

File:

PDF, 892 KB

english, 2000

38

Formaldehyde dehydrogenase: Beyond phase I metabolism

Chad M. Thompson, Rebecca Ceder, Roland C. Grafström

Journal:

Toxicology Letters

Year:

2010

Language:

english

File:

PDF, 361 KB

english, 2010

39

The ToxBank Data Warehouse: Supporting the Replacement of In Vivo Repeated Dose Systemic Toxicity Testing

Kohonen, Pekka, Benfenati, Emilio, Bower, David, Ceder, Rebecca, Crump, Michael, Cross, Kevin, Grafström, Roland C., Healy, Lyn, Helma, Christoph, Jeliazkova, Nina, Jeliazkov, Vedrin, Maggioni, Silvia

Journal:

Molecular Informatics

Year:

2013

Language:

english

File:

PDF, 1.20 MB

english, 2013

40

Growth and Characterization of Human Thymic Epithelial Cells in Primary Culture

BIRGER CHRISTENSSON, PETER BIBERFELD, ROLAND GRAFSTRÖM, GEORG MATELL

Journal:

Annals of the New York Academy of Sciences

Year:

1987

Language:

english

File:

PDF, 129 KB

english, 1987

41

Commentary: mechanistic considerations for associations between formaldehyde exposure and nasopharyngeal carcinoma

Chad M Thompson, Roland C Grafström

Journal:

Environmental Health

Year:

2009

Language:

english

File:

PDF, 1.50 MB

english, 2009

42

The effect of long term treatment with disulfiram on content of cytochrome P-450 and on benzo(a)pyrene monooxygenase activity in microsomes isolated from the rat small intestinal mucosa

Grafström, Roland, Holmberg, Bo

Journal:

Toxicology Letters

Year:

1980

Language:

english

File:

PDF, 471 KB

english, 1980

43

YAP1 is a potential biomarker for cetuximab resistance in head and neck cancer

Jerhammar, Fredrik, Johansson, Ann-Charlotte, Ceder, Rebecca, Welander, Jenny, Jansson, Agneta, Grafström, Roland C., Söderkvist, Peter, Roberg, Karin

Journal:

Year:

2014

Language:

english

File:

PDF, 1.22 MB

english, 2014

44

Bioinformatics Processing of Protein and Transcript Profiles of Normal and Transformed Cell Lines Indicates Functional Impairment of Transcriptional Regulators in Buccal Carcinoma

Staab, Claudia A., Ceder, Rebecca, Jägerbrink, Theres, Nilsson, Jan-Anders, Roberg, Karin, Jörnvall, Hans, Höög, Jan-Olov, Grafström, Roland C.

Journal:

Journal of Proteome Research

Year:

2007

Language:

english

File:

PDF, 686 KB

english, 2007

45

Cancer Biology, Toxicology and Alternative Methods Development Go Hand-in-Hand

Kohonen, Pekka, Ceder, Rebecca, Smit, Ines, Hongisto, Vesa, Myatt, Glenn, Hardy, Barry, Spjuth, Ola, Grafström, Roland

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2014

Language:

english

File:

PDF, 1.65 MB

english, 2014

46

Comparative Hazard Characterization in Food Toxicology

Hammerling, Ulf, Tallsjö, Annika, Grafström, Roland, Ilbäck, Nils-Gunnar

Journal:

Critical Reviews in Food Science and Nutrition

Year:

2009

Language:

english

File:

PDF, 4.04 MB

english, 2009

47

A 23 kDa membrane glycoprotein bearing NeuNAcα2-3Galβ1-3GalNAc O-linked carbohydrate chains acts as a receptor for Streptococcus sanguis OMZ 9 on human buccal epithelial cells

Neeser, Jean-Richard, Grafström, Roland C., Woltz, Arlerre, Brassart, Dominique, Fryder, Vincent, Guggenheim, Bernhard

Journal:

Year:

1995

Language:

english

File:

PDF, 1.09 MB

english, 1995

48

Studies on the role of oxygen radicals in asbestos-induced cytopathology of cultured human lung mesothelial cells

Gabrielson, Edward W., Rosen, Gerald M., Grafstrom, Roland C., Strauss, Karyn E., Harris, Curtis C.

Journal:

Year:

1986

Language:

english

File:

PDF, 425 KB

english, 1986

49

Consumption of Red/processed Meat and Colorectal Carcinoma: Possible Mechanisms underlying the Significant Association

Hammerling, Ulf, Laurila, Jonas Bergman, Grafström, Roland, Ilbäck, Nils-Gunnar

Journal:

Critical Reviews in Food Science and Nutrition

Year:

2015

Language:

english

File:

PDF, 715 KB

english, 2015

50

Thiol status and cytopathological effects of acrolein in normal and xeroderma pigmentosum skin fibroblasts

Dypbukt, Jeannette M., Atzori, Luigi, Edman, Charlotte C., Grafström, Roland C.

Journal:

Year:

1993

Language:

english

File:

PDF, 2.09 MB

english, 1993

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